Patrick J Brennan Selected Research

lipoarabinomannan (LAM)

1/2018	Detection of lipoarabinomannan in urine and serum of HIV-positive and HIV-negative TB suspects using an improved capture-enzyme linked immuno absorbent assay and gas chromatography/mass spectrometry.
1/2014	The challenge of producing skin test antigens with minimal resources suitable for human application against a neglected tropical disease; leprosy.
1/2014	Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.
11/2012	A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.
2/2011	Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.
10/2010	Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.
11/2008	Lipoarabinomannan of Mycobacterium: mannose capping by a multifunctional terminal mannosyltransferase.
1/2007	The cell-wall core of Mycobacterium tuberculosis in the context of drug discovery.
9/2006	Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase.
7/2006	Genetic basis for the synthesis of the immunomodulatory mannose caps of lipoarabinomannan in Mycobacterium tuberculosis.

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Patrick J Brennan Research Topics

Disease

36	Leprosy (Hansen's Disease) 12/2015 - 05/2002
35	Tuberculosis (Tuberculoses) 02/2015 - 03/2002
23	Infections 11/2023 - 07/2002
6	Neoplasms (Cancer) 04/2024 - 06/2007
5	Lepromatous Leprosy 02/2013 - 03/2005
3	Inflammation (Inflammations) 02/2024 - 01/2017
3	COVID-19 01/2023 - 01/2020
3	Surgical Wound Infection 02/2011 - 03/2003
2	Food Hypersensitivity (Food Allergy) 01/2023 - 01/2018
2	Asthma (Bronchial Asthma) 01/2023 - 12/2019
2	Multibacillary Leprosy 12/2012 - 09/2005
2	Urinary Tract Infections (Urinary Tract Infection) 02/2011 - 05/2010
2	Sepsis (Septicemia) 02/2011 - 05/2005
2	Paucibacillary Leprosy 12/2005 - 09/2005
2	Pulmonary Tuberculosis 12/2004 - 03/2002
1	Persistent Infection 04/2024
1	Fibrosis (Cirrhosis) 12/2023
1	Edema (Dropsy) 12/2023
1	Lymphedema (Milroy Disease) 12/2023
1	Drug Hypersensitivity (Drug Allergy) 01/2023
1	Immediate Hypersensitivity 01/2023
1	Drug-Related Side Effects and Adverse Reactions 01/2023
1	Postoperative Pain 03/2021
1	Pain (Aches) 03/2021
1	Mycobacterium Infections (Infections, Mycobacterium) 01/2021
1	red meat allergy 01/2020

Drug/Important Bio-Agent (IBA)

18	AntigensIBA 04/2024 - 03/2002
12	Proteins (Proteins, Gene)FDA Link 12/2023 - 07/2002
12	lipoarabinomannan (LAM)IBA 01/2018 - 05/2002
10	LipidsIBA 01/2017 - 03/2005
8	EnzymesIBA 02/2015 - 03/2002
8	Peptides (Polypeptides)IBA 01/2012 - 07/2003
6	GlycolipidsIBA 01/2020 - 05/2004
6	Recombinant ProteinsIBA 02/2011 - 09/2005
5	VaccinesIBA 01/2023 - 08/2002
5	CytokinesIBA 12/2019 - 03/2009
4	Mycolic Acids (Mycolic Acid)IBA 11/2012 - 12/2003
4	MannosidesIBA 01/2009 - 05/2002
3	RNA (Ribonucleic Acid)IBA 12/2023 - 12/2006
3	NucleotidesIBA 08/2019 - 09/2006
3	thiocarlideIBA 02/2015 - 11/2007
3	ProdrugsIBA 02/2015 - 08/2004
3	Tuberculin (PPD)IBA 01/2014 - 05/2007
3	Indicators and Reagents (Reagents)IBA 02/2013 - 12/2005
3	Glycoproteins (Glycoprotein)IBA 12/2011 - 07/2002
3	AntibodiesIBA 12/2011 - 05/2004
3	ImmunosorbentsIBA 09/2011 - 03/2002
3	lipomannanIBA 10/2010 - 05/2002
3	DNA (Deoxyribonucleic Acid)IBA 09/2009 - 09/2009
3	Interferon-gamma (Interferon, gamma)IBA 03/2009 - 09/2005
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2009 - 09/2003
3	GlycosyltransferasesIBA 09/2006 - 07/2002
2	SphingolipidsIBA 01/2023 - 01/2018
2	Uridine Diphosphate (UDP)IBA 12/2019 - 12/2010
2	LipopolysaccharidesIBA 01/2018 - 10/2010
2	Polysaccharides (Glycans)IBA 01/2018 - 06/2007
2	Type II Fatty Acid SynthaseIBA 02/2015 - 11/2012
2	Thioacetazone (Thiacetazone)IBA 02/2015 - 11/2012
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2014 - 10/2011
2	Biomarkers (Surrogate Marker)IBA 12/2012 - 09/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 11/2012 - 09/2003
2	EpitopesIBA 01/2012 - 06/2004
2	DisaccharidesIBA 12/2011 - 06/2010
2	Immunoglobulin M (IgM)IBA 12/2011 - 03/2002
2	Mycobacterium leprae phenolic glycolipid IIBA 12/2011 - 02/2011
2	Human Serum Albumin FDA LinkGeneric 12/2011 - 06/2010
2	AcidsIBA 07/2011 - 02/2011
2	Isoniazid (Ftivazide)FDA LinkGeneric 12/2009 - 08/2004
2	arabanIBA 11/2008 - 07/2006
2	SugarsIBA 06/2007 - 09/2006
1	Linoleic Acid (Linoleate)IBA 02/2024
1	Nonesterified Fatty Acids (NEFA)IBA 02/2024
1	Phospholipases A2 (Phospholipase A2)IBA 02/2024
1	Rosiglitazone (Avandia)FDA Link 12/2023
1	Caffeine (No Doz)FDA LinkGeneric 01/2023
1	ORALIT (ORS)IBA 01/2023
1	COVID-19 VaccinesIBA 01/2023
1	BNT162 VaccineIBA 01/2023
1	Amino Acids FDA Link 01/2023
1	Bile Acids and Salts (Bile Acids)IBA 01/2023
1	BilirubinIBA 01/2023
1	DiglyceridesIBA 01/2023
1	Hormones (Hormone)IBA 01/2023
1	Immunoglobulin E (IgE)IBA 01/2023
1	SteroidsIBA 01/2023
1	Vitamin D FDA LinkGeneric 01/2023
1	GTP-Binding Proteins (G-Protein)IBA 01/2023
1	Opioid Analgesics (Opioids)IBA 03/2021
1	Narcotics (Narcotic Analgesics)IBA 03/2021
1	CholesterolIBA 01/2021
1	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 12/2019
1	Interleukin-12 Subunit p40IBA 12/2019

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 12/2014 - 04/2004
4	Therapeutics 12/2023 - 07/2006
2	Catheters 02/2011 - 05/2010
1	Lymph Node Excision (Lymph Node Dissection) 12/2023
1	Critical Care (Surgical Intensive Care) 11/2023
1	Patient Transfer (Patient Dumping) 11/2023
1	Ambulatory Surgical Procedures (Outpatient Surgery) 03/2021
1	Mechanical Ventilators (Ventilator) 01/2020